Moderna’s bivalent COVID-19 booster offers improved protection against Omicron

Moderna’s bivalent COVID-19 booster offers improved protection against Omicron

Moderna’s Bivalent COVID-19 Booster:

Moderna’s bivalent COVID-19 booster vaccine candidate, mRNA-1273.211, demonstrated superior neutralizing titers compared to the original mRNA-1273 booster dose against all variants of concern, including Omicron, according to data released by the company this week.

mRNA-1273.211 targets mutations found in the Beta variant; several of which have been persistent in more recent variants of concern including Omicron.

 

Superiority against ancestral, Beta, Delta and Omicron variants

 

Moderna says the 50 µg booster dose of mRNA-1273.211 meets its objectives for a bivalent booster candidate; such as superiority immunogenicity criteria against variants of concern when compared to the mRNA-1273 booster dose (50 µg).

 

A booster dose of mRNA-1273.211 demonstrated superiority against the ancestral SARS-CoV-2 and the Beta; Delta and Omicron variants one month after the booster dose and superiority against the ancestral SARS-CoV-2, Beta and Omicron six months compared to the booster dose of mRNA-1273.

 

ALSO READ: Moderna trials Omicron-specific vaccine booster

 

There was a 2.20-fold (95% CI: 1.74, 2.79) and 2.15-fold (95% CI: 1.66, 2.78) increase in the neutralizing antibody titers against Omicron; with the mRNA-1273.211 booster dose compared to the mRNA-1273 booster dose at one month and six months, respectively.

 

The mRNA-1273.211 booster candidate was generally well tolerated in 300 study participants; who received the 50 µg dose and 595 participants who received the 100 µg dose of mRNA-1273.211 (895 participants in total).

 

​The 50 µg booster dose of mRNA-1273.211 had a similar incidence of solicited adverse reactions; and unsolicited adverse events with the authorized mRNA-1273 booster (50 µg).

About The Author

Osigweh Lilian Oluchi is a graduate of the University of Lagos where she obtained a B.A (Hons) in English, Masters in Public and International affairs (MPIA). Currently works with 1stnews as a Database Manager / Writer. [email protected]

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